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KMID : 0043320080310010021
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Archives of Pharmacal Research
2008 Volume.31 No. 1 p.21 ~ p.27
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A New Sesquiterpene and Other Terpenoid Constituents of Chisocheton penduliflorus
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Phongmaykin Jarinporn
Kumamoto Takuya
Ishikawa Tsutomu
Saifah Ekarin
Suttisri Rutt
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Abstract
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A new aromadendrane sesquiterpene, allo-aromadendrane-10, 14-diol (3), was isolated from Chisocheton penduliflorus (Meliaceae), along with two known sesquiterpenes: allo-aromadendrane-10, 13, 14-triol (7). Six dammarane triterpenoids, including cabraleadiol (1), eichlerialactone (4), cabraleahydroxylactone (5), cabralealactone (6), hollongdione (8) and dammaradienone (9), the coumarins scoparone and scopoletin, and vanillic acid were also isolated from the wood and leaves of this plant. Compounds 1-7 displayed antimycobacterial activity against Mycobacterium tuberculosis. Compounds 1, 4, 5 and 6 were weakly cytotoxic to a breast cancer (BC) cell line; whereas, compound 6 was moderately active against a small-cell lung cancer (NCI-H187) cell line.
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KEYWORD
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Chisocheton penduliflorus, Meliaceae, Aromadendrane sesquiterpenes, Dammarane triterpenes, Antimycobacterial activity, Cytotoxicity
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